Article

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugs

2026-04-07

Abstract excerpt

Peritendinous adhesions are a debilitating complication of tendon injury characterized by excessive matrix deposition and chronic inflammation. Due to limitations of current preclinical models, the underlying mechanisms of adhesion pathogenesis remain poorly defined, and there are no approved drugs to prevent or resolve adhesions. Here, we develop a human synovial tendon-on-a-chip (synToC) that integrates synovial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11327fc0-1b42-5f09-b097-47ecb9fb8811
DOI: 10.64898/2026.04.03.716316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugsDOI 10.64898/2026.04.03.716316Read

Human tendon-on-a-chip for modeling vascular inflammatory fibrosisSemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals ACKR1 migrates macrophages involve in endogenous regenerationSemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regenerationSemantic proximity Read

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomicsSemantic proximity Read

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendonSemantic proximity Read

Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendonSemantic proximity Read

Fluid Flow Impacts Endothelial-Monocyte Interactions in a Model of Vascular Inflammatory FibrosisSemantic proximity Read

Single cell multi-omics characterise discrete human tendon cells populations that persist in vitro and on fibrous scaffoldsSemantic proximity Read

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read

Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon researchSemantic proximity Read

Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendonsSemantic proximity Read

A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritisSemantic proximity Read