Article
Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation.
Integrative biology : quantitative biosciences from nano to macro - 7 Sept 2020
Walker Matthew, Godin Michel, Pelling Andrew E
Abstract excerpt
Developing methods to study tissue mechanics and myofibroblast activation may lead to new targets for therapeutic treatments that are urgently needed for fibrotic disease. Microtissue arrays are a promising approach to conduct relatively high-throughput research into fibrosis as they recapitulate key biomechanical aspects of the disease through a relevant 3D extracellular environment. In early work, our group...
Topics
- Actins
- Animals
- Cell Culture Techniques
- Cell Differentiation
- Cells, Cultured
- Extracellular Matrix
- Fibroblasts
- Fibrosis
- Lung
- Mice
- Muscle, Smooth
- Myofibroblasts
- NIH 3T3 Cells
- Phenotype
- Signal Transduction
- Stress, Mechanical
- Transforming Growth Factor beta1