Article

Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon Explants

2026-03-09

Abstract excerpt

Extracellular matrix (ECM) remodeling is essential for adaptation to changing mechanical demands, yet the mechanisms linking altered strain to functional outcomes remain poorly understood. This study aimed to define molecular and cellular programs driving the adaptation of tendon to increased (exercise) and decreased (disuse) strain. Male murine flexor tendon explants were cultured in incubator-housed tensile bior...

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Literature Corpus work: 192a887c-7a37-50d2-a2fc-65531134f9e4
DOI: 10.64898/2026.03.05.709185

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