Article

Human tendon-on-a-chip for modeling vascular inflammatory fibrosis

2023-12-13

Abstract excerpt

<title>Abstract</title> <p>Understanding vascular inflammation and myofibroblast crosstalk is critical to developing therapies for fibrotic diseases. Here we report the development of a novel human Tendon-on-a-Chip (hToC) to model this crosstalk in peritendinous adhesions, a debilitating fibrotic condition affecting flexor tendon, which currently lacks biological therapies. The hToC enables cellular and paracrine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72b7a6e8-1831-519a-a00e-7c7abaf4ae8c
DOI: 10.21203/rs.3.rs-3722255/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human tendon-on-a-chip for modeling vascular inflammatory fibrosisDOI 10.21203/rs.3.rs-3722255/v1Read

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugsSemantic proximity Read

Fluid Flow Impacts Endothelial-Monocyte Interactions in a Model of Vascular Inflammatory FibrosisSemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals ACKR1 migrates macrophages involve in endogenous regenerationSemantic proximity Read

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read

Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendonSemantic proximity Read

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomicsSemantic proximity Read

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regenerationSemantic proximity Read

Single cell multi-omics characterise discrete human tendon cells populations that persist in vitro and on fibrous scaffoldsSemantic proximity Read

Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendonSemantic proximity Read

Longitudinal <i>in vivo</i> human wound healing model defines key role for smooth muscle cells in ECM remodelingSemantic proximity Read

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendonSemantic proximity Read

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathySemantic proximity Read