Article

CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling

2025-03-10

Abstract excerpt

<h4>Background</h4> Fibrosis is a major cause of morbidity and mortality in rheumatic connective tissue diseases. In these conditions, fibrotic tissues are characterized by the infiltration of CD8+ T cells and pro-fibrotic myofibroblasts. However, the role of CD8+ T cells in driving myofibroblast activity remains unexplored. Our aim was to investigate this interaction between CD8+ T cells and skin myofibroblasts...

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Literature Corpus work: 2dd153c4-1cd6-574f-b158-5c57375ce6fb
DOI: 10.1101/2025.03.05.641635

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