Article

IFNγ and proinflammatory cytokines cooperatively license astrocytes to support antigen-dependent CD4+ T cell restimulation

2026-08-04

Abstract excerpt

We report that type 2 interferon with proinflammatory cytokines induces astrocytes to express multiple components required for attraction of and antigen presentation to CD4+ T cells via MHC-II molecules. Re-analysis of astrocyte-enriched single-cell sequencing from bacterial mimetic-injected mice revealed a transcriptionally distinct interferon-responsive astrocyte population enriched for antigen-presentation-asso...

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Identifiers and source

Literature Corpus work: 485ca577-dce2-569e-bd6d-fdc47bad876a
DOI: 10.64898/2026.07.29.741554

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