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Article

The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes.

Journal of neuroinflammation - 16 Apr 2022

West Phillip K, McCorkindale Andrew N, Guennewig Boris, Ashhurst Thomas M, Viengkhou Barney, Hayashida Emina, Jung So Ri, Butovsky Oleg, Campbell Iain L, Hofer Markus J

Abstract excerpt

BACKGROUND: Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectrum disorders or cerebral interferonopathies, respectively. Transgenic mice with CNS-targeted chronic production of IL-6 (GFAP-IL6) or IFN-α (GFAP-IFN) recapitulate important clinical and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35429976
DOI: 10.1186/s12974-022-02441-x
PMCID: PMC9013466

Genes

GFAP
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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