Article

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

2022-04-10

Abstract excerpt

The contribution of circulating verses tissue resident memory T cells (TRM) to clinical neuropathology is an enduring question due to a lack of mechanistic insights. The prevailing view is TRM cells are protective against pathogens in the brain. However, the extent antigen-specific TRM cells can induce neuropathology upon reactivation has not been determined. Using the described phenotype of TRMs, we found that br...

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Literature Corpus work: 7467ec4e-4e99-5ace-aaa7-1dbe1d019119
DOI: 10.1101/2022.04.08.487707

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