Article

Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation

2025-06-27

Abstract excerpt

Astrocytes adapt to injury and disease by entering a reactive state defined by transcriptomic, morphological, and functional changes. Using a combination of human cortical organoids (hCOs) and primary fetal brain tissue, we investigated the plasticity of human astrocyte reactivity. We observed robust inflammatory transcriptomic and chromatin signatures following cytokine exposure, which varied with duration. To as...

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Identifiers and source

Literature Corpus work: 10483ebd-eb76-544c-bdb8-b1b335ae9328
DOI: 10.1101/2025.06.26.661787

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