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Article

Optimization of a neuron-microglia co-culture model to explore cell-to-cell interaction dynamics.

Frontiers in immunology - 1 Jan 2026

Vogiatzis Stefania, Severa Martina, Pietrantoni Agostina, Cairo Giada, Falco Roberta Pia, Veroni Caterina, Lanciotti Angela, Etna Marilena Paola, Abate Davide Antonio, Nencioni Lucia, Trevisan Marta, Coccia Eliana Marina, Barzon Luisa

Abstract excerpt

Introduction: The dialogue between the immune and nervous systems in the central nervous system (CNS) is a fundamental challenge in neuroscience and neuroimmunology. Microglia, the brain's resident immune cells, continuously communicate with neurons to maintain brain homeostasis, support development, and orchestrate responses to injury. Methods: We adapted the CEBPA/SPI1 transcription factor overexpression...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42568588
DOI: 10.3389/fimmu.2026.1850795
PMCID: PMC13447273

Genes

GPR34
MMP9
SPI1
TMEM119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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