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Investigating the Effects of <i>APOE</i> Genotype on Intracellular Cholesterol and the Endolysosomal System in the Aging Mouse Brain

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Individuals who possess the ε4 allele of apolipoprotein E ( APOE ) are at a significantly increased risk for developing Alzheimer’s disease (AD). However, the precise reason for this association is not fully understood. Beyond its effects on amyloid and tau, APOE also influences fundamental cellular processes in the brain, including cholesterol trafficking between cells and within the endolyso...

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Literature Corpus work
479810ea-e506-57d4-8843-0226768dc2a5
DOI
10.1101/2025.11.11.687891
Open publication

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Investigating the Effects of <i>APOE</i> Genotype on Intracellular Cholesterol and the Endolysosomal System in the Aging Mouse BrainDOI 10.1101/2025.11.11.687891
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