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The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age- and sex-dependent.

Journal of neurochemistry - 1 Sept 2024

den Hoedt Sandra, Crivelli Simone M, Dorst-Lagerwerf Kristien Y, Leijten Frank P J, Losen Mario, de Vries Helga E, Sijbrands Eric J G, Verhoeven Adrie J M, Martinez-Martinez Pilar, Mulder Monique T

Abstract excerpt

APOE4 encoding apolipoprotein (Apo)E4 is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is key in intercellular lipid trafficking. Fatty acids are essential for brain integrity and cognitive performance and are implicated in neurodegeneration. We determined the sex- and age-dependent effect of AD and APOE4 on brain free fatty acid (FFA) profiles. FFA profiles were determined by LC-MS/MS in...

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Age Factors
Aging
Alzheimer Disease
Apolipoprotein E4
Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fatty Acids, Nonesterified

Mice, Transgenic

Sex Characteristics

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PMID: 39001667
DOI: 10.1111/jnc.16176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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