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Article

Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain

9 May 2014

Abstract excerpt

Elderly females, particularly those carrying the apolipoprotein E (ApoE)-ε4 allele, have a higher risk of developing Alzheimer's disease (AD). However, the underlying mechanism for this increased susceptibility remains unclear. In this study, we investigated the effects of the ApoE genotype and gender on the proteome of synaptosomes. We isolated synaptosomes and used label-free quantitative proteomics, to report,...

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PMID: 24810422
DOI: 10.1017/s1461145714000601

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