Article

<i>APOE4</i> exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction

2025-02-05

Abstract excerpt

APOE4 is the leading genetic risk factor for Alzheimer’s disease, and chronic stress is a leading environmental risk factor. Studies suggest that APOE4 confers vulnerability to the behavioral and neuropathological effects of chronic stress, representing a potential mechanism by which this genetic variant accelerates Alzheimer’s onset and progression. Whether and how APOE4 -mediated stress vulnerability manifests...

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Literature Corpus work: 76938bd6-cd83-54f9-8e40-e24dfe4c3c8c
DOI: 10.1101/2025.02.03.636364

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