Article

<i>APOE4</i> drives widespread changes to the hepatic proteome and alters metabolic function

2025-06-19

Abstract excerpt

Apolipoprotein E (APOE) is essential for lipid homeostasis and has been extensively studied in the central nervous system, particularly in the context of Alzheimer’s disease (AD). Individuals carrying an APOE4 allele have an increased risk of AD and exhibit deficits in energy metabolism, including glucose utilization and mitochondrial dysfunction. While the role of APOE in the liver is well characterized, the imp...

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Literature Corpus work: 2f048cf3-32b5-5e07-83df-21d4bca3c245
DOI: 10.1101/2025.06.15.659815

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