Article

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

2024-03-14

Abstract excerpt

<h4>Summary</h4> Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between isoforms remains unknown. Here, we systematically compared 693 isoforms of 246 TF genes, assessing DNA binding, protein binding, transcriptional activation, subcellular...

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Literature Corpus work: 478b2526-7345-50c9-8729-f62ecece2e14
DOI: 10.1101/2024.03.12.584681

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