Article

Graph-based tracing of dynamically functioning gene circuits in cell fate decisions with isoform resolution

2025-10-23

Abstract excerpt

Transcription factor (TF) regulatory networks govern complex cellular processes, yet their inference from single-cell transcriptomes is hindered by TFs’ low abundance, tissue-specific functions, and isoform diversity. We evaluated the utility of transcription factor activity (TFA) to infer TF–TF interactions, demonstrating its superiority over expression-based methods in capturing tissue-specific, high-fidelity re...

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Literature Corpus work: eb0559e7-4552-542f-a1f4-df9fca844735
DOI: 10.1101/2025.10.21.683820

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