Article

Aberrant splicing in human cancer has a large-scale functional impact on transcription factors

2025-10-16

Abstract excerpt

Cancer shows aberrant alternative splicing (AS), which could functionally perturb proteins required for normal cellular behavior. Transcription factors (TFs) are proteins that regulate gene transcription. Some evidence about AS-driven perturbation of TFs in cancer has been documented. A comprehensive systematic analysis of how cancer-specific AS could affect functions of TFs is missing. Such an analysis could reve...

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Literature Corpus work: 8c4e2775-5b0d-565d-bb3f-42c34f44a496
DOI: 10.1101/2025.10.16.682783

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