Aberrant splicing in human cancer has a large-scale functional impact on transcription factors

Abstract excerpt

<title>Abstract</title> <p>Cancer shows aberrant alternative splicing (AS), which could functionally perturb proteins required for normal cellular behavior. Transcription factors (TFs) are proteins that regulate gene transcription. Some evidence about AS-driven perturbation of TFs in cancer has been documented. A comprehensive systematic analysis of how cancer-specific AS could affect functions of TFs is missing....

Topics

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• Gene Expression Regulation, Neoplastic
• Mutation
• Neoplasms
• Neurogenetic and Muscular Disorders Research
• RNA modifications and cancer
• RNA Research and Splicing
• RNA Splicing
• RNA Splicing Factors

Identifiers and source

Literature Corpus work

f31caa15-2fa2-5627-a1ac-9704df0583fe

DOI

10.21203/rs.3.rs-7799323/v1