Article

Expression and Splicing Mediate Distinct Biological Signals

2022-08-29

Abstract excerpt

<h4>Background</h4> Through alternative splicing, most human genes produce multiple isoforms in a cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing is essential for development, diseases and their treatments. Despite these important examples, the extent and biological relevance of splicing are currently unknown. <h4>Results</h4> To solve this problem, we developed paire...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d84b29d-c9d3-5f0f-a0e2-6910fe5de9ea
DOI: 10.1101/2022.08.29.505720

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression and Splicing Mediate Distinct Biological SignalsDOI 10.1101/2022.08.29.505720Read

Alternative splicing is coupled to gene expression in a subset of variably expressed genesSemantic proximity Read

Selecting differential splicing methods: Practical considerationsSemantic proximity Read

Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissuesSemantic proximity Read

RNA sequencing depth guidelines for the study of alternative splicingSemantic proximity Read

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversitySemantic proximity Read

Dissecting splicing decisions and cell-to-cell variability with designed sequence librariesSemantic proximity Read

Transcript isoform differences across human tissues are predominantly driven by alternative start and termination sites of transcriptionSemantic proximity Read

Genetic variation of pre-mRNA alternative splicing in human populations.Semantic proximity Read

<i>SplAdder</i> : Identification, quantification and testing of alternative splicing events from RNA-Seq dataSemantic proximity Read

The Expanding Landscape of Alternative Splicing Variation in Human Populations.Semantic proximity Read

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing EventsSemantic proximity Read

Deciphering the Genetic Orchestra: Unveiling Splice Form Dynamics in Human Cell LinesSemantic proximity Read