Article
A comprehensive survey for human transcription factors on expression, regulation, interaction, phenotype and cancer survival.
Briefings in bioinformatics - 2 Sept 2021
Hu Hui, Zhang Qiong, Hu Fei-Fei, Liu Chun-Jie, Guo An-Yuan
Abstract excerpt
Transcription factors (TFs) act as key regulators in biological processes through controlling gene expression. Here, we conducted a systematic study for all human TFs on the expression, regulation, interaction, mutation, phenotype and cancer survival. We revealed that the average expression levels of TFs in normal tissues were lower than 50% expression of non-TFs, whereas TF expression was increased in cancers....
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