Article

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

2021-10-03

Abstract excerpt

<h4>SUMMARY</h4> Comprehensive sequencing of patient tumors reveals numerous genomic mutations across tumor types that enable tumorigenesis and progression. A subset of oncogenic driver mutations results in neomorphic activity where the mutant protein mediates functions not engaged by the parental molecule. Here, we identify prevalent variant-enabled neomorph-protein-protein interactions (neoPPI) with a q uantit...

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Literature Corpus work: 470ec838-93bf-54d2-b1e8-0c98ab0f0c0e
DOI: 10.1101/2021.10.03.462422

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