Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions.

doi:10.1038/s42003-023-05089-2

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Article

Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions.

Communications biology - 13 Jul 2023

Kugler Valentina, Lieb Andreas, Guerin Nathan, Donald Bruce R, Stefan Eduard, Kaserer Teresa

Abstract excerpt

We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyse both protein-protein and protein-DNA interfaces and it is validated on a dataset of clinically relevant mutations. In addition, it is used to predict previously uncharacterised patient mutations in CDK6 and p16 genes, which are experimentally...

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PMID: 37443295
DOI: 10.1038/s42003-023-05089-2
PMCID: PMC10344873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.