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CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunities

2026-01-23

Abstract excerpt

Identifying cancer driver genes and mutations remains a cornerstone of cancer research and a prerequisite for developing effective targeted therapies. While current approaches have successfully uncovered recurrent oncogenic alterations, they often miss rare or context specific events, leaving large segments of the mutational landscape of human cancers functionally uncharacterised. We developed a CRISPR enhanced an...

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Literature Corpus work
86960cda-9f62-5f93-99f1-5ef829858d76
DOI
10.64898/2026.01.20.700565
Open publication

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CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunitiesDOI 10.64898/2026.01.20.700565
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