Article

Discovering chromatin dysregulation induced by protein-coding perturbations at scale

2023-09-21

Abstract excerpt

Although population-scale databases have expanded to millions of protein-coding variants, insight into variant mechanisms has not kept pace. We present PROD-ATAC, a high-throughput method for discovering the effects of protein-coding variants on chromatin. A pooled library of variants is expressed in a disease-agnostic cell line, and single-cell ATAC resolves each variant’s effect on chromatin. Using PROD-ATAC, we...

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Literature Corpus work: 9ddcce01-9654-587c-8427-6ce5b4102f87
DOI: 10.1101/2023.09.20.555752

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