Article
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Cell - 26 May 2022
Mo Xiulei, Niu Qiankun, Ivanov Andrey A, Tsang Yiu Huen, Tang Cong, Shu Changfa, Li Qianjin, Qian Kun, Wahafu Alafate, Doyle Sean P, Cicka Danielle, Yang Xuan, Fan Dacheng, Reyna Matthew A, Cooper Lee A D, Moreno Carlos S, Zhou Wei, Owonikoko Taofeek K, Lonial Sagar, Khuri Fadlo R, Du Yuhong, Ramalingam Suresh S, Mills Gordon B, Fu Haian
Abstract excerpt
Comprehensive sequencing of patient tumors reveals genomic mutations across tumor types that enable tumorigenesis and progression. A subset of oncogenic driver mutations results in neomorphic activity where the mutant protein mediates functions not engaged by the parental molecule. Here, we identify prevalent variant-enabled neomorph-protein-protein interactions (neoPPI) with a quantitative high-throughput...
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