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Article

Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook.

STAR protocols - 20 Dec 2024

Chen Hongyue, Revennaugh Brian, Fu Haian, Ivanov Andrey A

Abstract excerpt

While some tumor driver mutations inhibit existing protein-protein interactions (PPIs), others can create neomorph interactions (neoPPIs) not characteristic of the wild-type counterparts. Such tumor-specific neoPPIs may represent targets for therapeutic interventions. Here, we present a protocol to computationally uncover neoPPI-enabled druggable tumor dependencies using the AVERON Notebook environment. We...

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Identifiers

PMID: 39520688
DOI: 10.1016/j.xpro.2024.103441
PMCID: PMC11585674

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