Article

Systematic Pan-cancer Functional Inference and Validation of Hyper, Hypo and Neomorphic Mutations

2023-04-30

Abstract excerpt

While the functional effects of many recurrent cancer mutations have been characterized, the TCGA repository comprises more than 10M non-recurrent events, whose function is unknown. We propose that the context specific activity of transcription factor (TF) proteins—as measured by expression of their transcriptional targets—provides a sensitive and accurate reporter assay to assess the functional role of oncoprotei...

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Literature Corpus work: 2861f947-3640-5487-a085-4e251d1cd5ec
DOI: 10.1101/2023.04.29.538640

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