Article

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

2024-03-21

Abstract excerpt

Survival for metastatic breast cancer is low and thus, continued efforts to treat and prevent metastatic progression are critical. Estrogen is shown to promote aggressive phenotypes in multiple cancer models irrespective of estrogen receptor (ER) status. Similarly, UDP-Glucose 6-dehydrogenase (UGDH) a ubiquitously expressed enzyme involved in extracellular matrix precursors, as well as hormone processing increases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46d9b7bd-0004-5acb-a4d1-91fd55e9c697
DOI: 10.1101/2024.03.20.585919

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UDP-6-glucose dehydrogenase in hormonally responsive breast cancersDOI 10.1101/2024.03.20.585919Read

UDP-Glucose 6-Dehydrogenase Knockout Impairs Migration and Decreases <i>in vivo</i> Metastatic Ability of Breast Cancer CellsSemantic proximity Read

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancerSemantic proximity Read

Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insightsSemantic proximity Read

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older womenSemantic proximity Read

Investigating the Roles of YWHAB in Breast CancerSemantic proximity Read

ECD co-operates with ERBB2 to promote tumorigenesis through upregulation of unfolded protein response and glycolysisSemantic proximity Read

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.Semantic proximity Read

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.Semantic proximity Read

Minimal residual disease in breast cancer and gynecological malignancies: phenotype and clinical relevance.Semantic proximity Read

A Developmental Lectin-Glycan Program Enables Early Breast Cancer Dissemination and Metastatic OnsetSemantic proximity Read

Expression of β-globin by cancer cells promotes cell survival during blood-borne disseminationSemantic proximity Read

MMP1-induced NF-κB activation promotes epithelial–mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancerSemantic proximity Read