Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.

Breast cancer research and treatment - 1 Dec 2013

Abdel-Fatah Tarek M A, Albarakati Nada, Bowell Lara, Agarwal Devika, Moseley Paul, Hawkes Claire, Ball Graham, Chan Stephen, Ellis Ian O, Madhusudan Srinivasan

Abstract excerpt

Uracil in DNA is an important cause of mutagenesis. SMUG1 is a uracil-DNA glycosylase that removes uracil through base excision repair. SMUG1 also processes radiation-induced oxidative base damage as well as 5-fluorouracil incorporated into DNA during chemotherapy. We investigated SMUG1 mRNA expr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotherapy, Adjuvant

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Receptors, Estrogen

Share to Tumor Burden

Share to Uracil-DNA Glycosidase

Source

Identifiers

PMID: 24253812
DOI: 10.1007/s10549-013-2769-6

Genes

SMUG1
ATM
BRCA1
MDM2
MDM4
MIB1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24253812-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.PMID 24253812Read ↗

Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.Semantic proximity Read ↗

SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidanceSemantic proximity Read ↗

Pan-Cancer Genetic Analysis of Mitochondrial DNA Repair Gene SetSemantic proximity Read ↗

Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast CancerSemantic proximity Read ↗

Elevated YBX1 mRNA expression is associated with a genomically unstable and clinically aggressive cancer state: a pan-cancer analysisSemantic proximity Read ↗

Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.Semantic proximity Read ↗

Germline mutations of the DNA repair pathways in uterine serous carcinoma.Semantic proximity Read ↗

Role of uridine phosphorylase 1 in cancer: A comprehensive pan-cancer analysis highlighting its prognostic and therapeutic potential.Semantic proximity Read ↗

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.Semantic proximity Read ↗

Targeting XRCC1 Deficiency in Breast Cancer for Personalized TherapySemantic proximity Read ↗

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.Semantic proximity Read ↗

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.