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Article

Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

28 May 2025

Abstract excerpt

Breast cancer remains the most prevalent malignancy among women globally, with its complexity linked to genetic variations and metabolic alterations within tumor cells. This study investigates the role of fumarate hydratase (FH), a key enzyme in the tricarboxylic acid (TCA) cycle, in breast cancer progression. Our findings reveal that FH mRNA and protein levels are significantly upregulated in breast cancer...

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PMID: 40437625
DOI: 10.1186/s40170-025-00397-z

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