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Article

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.

Breast cancer research : BCR - 1 Oct 2018

Sethuraman Aarti, Brown Martin, Krutilina Raya, Wu Zhao-Hui, Seagroves Tiffany N, Pfeffer Lawrence M, Fan Meiyun

Abstract excerpt

BACKGROUND: Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This study aimed to elucidate the function of BHLHE40 in the metastatic process of breast cancer cells. METHODS: To define the role of BHLHE40 in breast cancer, BHLHE40 expression was knocked down by a...

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Source

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Identifiers

PMID: 30285805
DOI: 10.1186/s13058-018-1046-3
PMCID: PMC6167787

Genes

BHLHE40
HBEGF
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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