Article

A Developmental Lectin-Glycan Program Enables Early Breast Cancer Dissemination and Metastatic Onset

2026-02-25

Abstract excerpt

<h4>SUMMARY</h4> Early dissemination of breast cancer cells can occur before clinically detectable tumor progression; yet the molecular programs enabling this process remain poorly defined. Here, we identify a conserved glycocheckpoint, mediated by the galectin-1 (GAL1)-glycan axis, that links normal mammary gland morphogenesis to early breast cancer dissemination and metastasis. During mammary gland development,...

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Literature Corpus work: 3f6194e2-2326-5e05-922f-eb6b42949078
DOI: 10.64898/2026.02.23.707584

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