Article

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

2022-10-07

Abstract excerpt

Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs) that are supported by a complex extracellular matrix (ECM) and immunosuppressive microenvironment. To target TICs to pr...

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Literature Corpus work: 41eb63a2-eb3d-55d0-bcb2-bb406ad2ac10
DOI: 10.1101/2022.10.07.509566

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