Article
Estrogen promotes tumor phenotypes in ER+ and ER- breast cancer through UGDH-GPR30.
JCI insight - 8 Sept 2026
Price Meghan J, Nguyen Annee D, Strawser Corinne H, Trivedi Trupti, Baeta Cesar Cd, Lavau Catherine, Byemerwa Jovita K, Mukherjee Debarati, Wardell Suzanne E, Artham Sandeep, Kumar Vardhman, Varghese Shyni, Goodwin C Rory
Abstract excerpt
Estrogen can promote aggressive tumor phenotypes in estrogen receptor-positive (ER+) breast cancer; however, ER- cell lines are not widely considered estrogen responsive. Noncanonical estrogen-stimulated pathways such as the membrane-bound G protein-coupled estrogen receptor (GPR30) can mediate migratory and proliferative phenotypes in breast cancer and are postulated to promote resistance to aromatase therapies....
Read the complete abstract on PubMedTopics
- Humans
- Receptors, G-Protein-Coupled
- Female
- Breast Neoplasms
- Receptors, Estrogen