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Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

9 Feb 2017

Abstract excerpt

Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs from breast, prostate and lung cancers, we observe consistent induction of β-globin (HBB), but not its partner α-globin (HBA). The tumour-specific origin of HBB is confirmed by sequence polymorphisms within...

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PMID: 28181495
DOI: 10.1038/ncomms14344

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