Article

ECD co-operates with ERBB2 to promote tumorigenesis through upregulation of unfolded protein response and glycolysis

2025-02-01

Abstract excerpt

<h4>ABSTRACT</h4> The ecdysoneless (ECD) mRNA and protein are overexpressed in breast cancer (BC), and its overexpression correlates with poor prognosis and short patient survival, particularly in ERBB2/HER2-positive BC. This study investigates the co-operative oncogenic mechanism of ECD and ERBB2 by deriving transgenic mice overexpressing ECD and/or ERBB2 (huHER2) in mammary epithelium under MMTV promoter, as we...

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Literature Corpus work: b3c63ec9-01d8-5b3e-b626-a25b062bd79d
DOI: 10.1101/2025.01.28.635284

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