Article

<i>Dexi</i> disruption depletes gut microbial metabolites and accelerates autoimmune diabetes

2018-08-16

Abstract excerpt

Non-coding genetic variants in the CLEC16A gene on human chromosome 16p13.13 are associated with risk of autoimmune diseases, including type 1 diabetes and multiple sclerosis. In this region, we previously identified DEXI , a candidate causal gene of unknown function, which alters the risk of type 1 diabetes, where the T1D predisposing allele is associated with lower DEXI expression. Here, we demonstrate by CRIS...

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Literature Corpus work: 4666a76c-8569-5702-9f24-706c0cc86eaa
DOI: 10.1101/393421

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