Article

Genetic variance in the murine defensin locus modulates glucose homeostasis

2024-07-26

Abstract excerpt

Insulin resistance is a heritable risk factor for many chronic diseases; however, the genetic drivers remain elusive. In seeking these, we performed genetic mapping of insulin sensitivity in 670 chow-fed Diversity Outbred in Australia (DOz) mice and identified a genome-wide significant locus (QTL) on chromosome 8 encompassing 17 defensin genes. By taking a systems genetics approach, we ultimately identified alpha-...

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Literature Corpus work: d270d76d-6ae5-56e3-9cc6-97571cf2ad2d
DOI: 10.1101/2024.07.25.605202

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