Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.

doi:10.1186/s40168-018-0417-4

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Article

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.

Microbiome - 17 Feb 2018

Mullaney Jane A, Stephens Juliette E, Costello Mary-Ellen, Fong Cai, Geeling Brooke E, Gavin Patrick G, Wright Casey M, Spector Timothy D, Brown Matthew A, Hamilton-Williams Emma E

Abstract excerpt

BACKGROUND: Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD)...

Topics

Animals
CTLA-4 Antigen
Cation Transport Proteins
Clostridiales
Diabetes Mellitus, Type 1
Dysbiosis
Female
Gastrointestinal Microbiome
Gastrointestinal Tract
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-2

Mice

Mice, Inbred C57BL

Mice, Inbred NOD

Ruminococcus

Source

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Identifiers

PMID: 29454391
DOI: 10.1186/s40168-018-0417-4
PMCID: PMC5816355

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