Article

The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset

2024-06-17

Abstract excerpt

Type 1 Diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. The insulin B-chain 9-23 (insB:9-23) peptide is established as a critical epitope in triggering T1D. In our previous study, we showed that Parabacteroides distasonis , a human gut commensal, contains an insB:9-23 mimic in its hprt protein (residues, 4-18). This mimic (hprt4-18) activates insB:9-23...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d48d4a15-d069-5e52-a6bb-7852aed92239
DOI: 10.1101/2024.06.13.598927

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes OnsetDOI 10.1101/2024.06.13.598927Read

Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onsetSemantic proximity Read

A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 DiabetesSemantic proximity Read

Gut microbiome in type 1 diabetes: A comprehensive reviewSemantic proximity Read

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis.Semantic proximity Read

Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in MiceSemantic proximity Read

Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD miceSemantic proximity Read

Gut microbiota mediated T cells regulation and autoimmune diseasesSemantic proximity Read

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic miceSemantic proximity Read

Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?Semantic proximity Read

A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetesSemantic proximity Read

The human gut microbiome in early-onset type 1 diabetes from the TEDDY studySemantic proximity Read

Gut colonization by <i>Bacteroides fragilis</i> at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic miceSemantic proximity Read