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Article

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

Nature genetics - 1 Apr 2006

Kissler Stephan, Stern Patrick, Takahashi Kazue, Hunter Kara, Peterson Laurence B, Wicker Linda S

Abstract excerpt

Type 1 diabetes is an autoimmune disease influenced by multiple genetic loci. Although more than 20 insulin-dependent diabetes (Idd) loci have been implicated in the nonobese diabetic (NOD) mouse model, few causal gene variants have been identified. Here we show that RNA interference (RNAi) can be used to probe candidate genes in this disease model. Slc11a1 encodes a phagosomal ion transporter, Nramp1, that...

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Identifiers

PMID: 16550170
DOI: 10.1038/ng1766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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