Article

Obesity-related alterations in plasma metabolomics and fecal microbiota in Down syndrome Dp(16)1Yey mice

2026-04-16

Abstract excerpt

<h4>Background/Objectives</h4> Individuals with Down syndrome (DS) are at increased risk of obesity and metabolic comorbidities, yet the mechanisms underlying these conditions remain unclear. Here we investigated how DS-associated genetic condition interacts with diet and metabolic pathways in the Dp(16)1Yey mouse model of DS. <h4>Methods</h4> Untargeted plasma metabolomics was performed in Dp(16)1Yey and contro...

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Literature Corpus work: 2df3f271-1143-59d4-9b2e-7b33c516d524
DOI: 10.64898/2026.04.10.717726

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