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Diabetes Susceptibility Genes <i>Pdx1</i> and <i>Clec16a</i> Function in a Pathway Regulating Mitophagy in β-Cells

17 Jun 2015

Abstract excerpt

Mitophagy is a critical regulator of mitochondrial quality control and is necessary for elimination of dysfunctional mitochondria to maintain cellular respiration. Here, we report that the homeodomain transcription factor Pdx1, a gene associated with both type 2 diabetes and monogenic diabetes of the young, regulates mitophagy in pancreatic β-cells. Loss of Pdx1 leads to abnormal mitochondrial morphology and...

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PMID: 26085571
DOI: 10.2337/db15-0376

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Related research

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Diabetes Susceptibility Genes <i>Pdx1</i> and <i>Clec16a</i> Function in a Pathway Regulating Mitophagy in β-CellsPMID 26085571Read ↗

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