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Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onset

1 Aug 2025

Abstract excerpt

Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic β-cells. The insulin B-chain 9-23 (insB9-23) peptide is a critical epitope in triggering T1D. In our previous study, we showed that Parabacteroides distasonis, a human gut commensal, contains an insB9-23 mimic in its hprt protein (residues 4-18). This mimic (hprt4-18) peptide activates insB9-23-specific T cells, and P. distasonis colonization...

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PMID: 40823966
DOI: 10.1530/jme-25-0025

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