Article

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation

2018-10-24

Abstract excerpt

It is becoming increasingly clear that brain network organization shapes the course and expression of neurodegenerative diseases. Parkinson’s disease (PD) is marked by progressive spread of atrophy from the midbrain to subcortical structures and eventually, to the cerebral cortex. Recent discoveries suggest that the neurodegenerative process involves the misfolding and prion-like propagation of endogenous α -synu...

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Literature Corpus work: 4659c481-ef6f-5e11-878f-6d961faea09e
DOI: 10.1101/449199

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