Article

Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages: a worldwide ENIGMA study

2025-05-27

Abstract excerpt

Parkinson’s disease (PD) is associated with extensive structural brain changes. Recent work has proposed that the spatial pattern of disease pathology is shaped by both network spread and local vulnerability. However, only few studies assessed these biological frameworks in large patient samples across disease stages. Analyzing the largest imaging cohort in PD to date (N = 3,096 patients), we investigated the role...

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Literature Corpus work: 4000bc17-bd13-52f3-b5ad-04f29f603a59
DOI: 10.1101/2025.05.25.25326586

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