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Article

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.

Neurobiology of disease - 15 Jun 2022

Henderson Michael X, Henrich Martin T, Geibl Fanni F, Oertel Wolfgang H, Brundin Patrik, Surmeier D James

Abstract excerpt

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor dysfunction is only one of many symptoms experienced by patients. A neuropathological hallmark of PD is intraneuronal protein aggregates called Lewy pathology (LP). Neuropathological staging studies have shown that dopaminergic neurons are only...

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Identifiers

PMID: 35283326
DOI: 10.1016/j.nbd.2022.105687
PMCID: PMC9610381

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