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Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression

20 May 2022

Abstract excerpt

Isolated REM sleep behaviour disorder (iRBD) is a synucleinopathy characterized by abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop dementia with Lewy bodies, Parkinson's disease or multiple system atrophy over time. Patients with iRBD exhibit brain atrophy patterns that are reminiscent of those observed in overt synucleinopathies. However, the mechanisms linking brain atrophy to...

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PMID: 35594873
DOI: 10.1093/brain/awac187

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