Article

Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like <i>α</i> -synuclein propagation

2026-03-31

Abstract excerpt

The spread of misfolded proteins through neuronal circuits is a defining feature of neurodegenerative disease, yet the dynamics underlying this process remain poorly understood. Most studies rely on sparsely sampled datasets that capture spatial patterns of pathology but not their temporal evolution. Here, we analyze longitudinal histopathology measurements of α -synuclein pathology across hundreds of brain regio...

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Literature Corpus work: c7b5de56-db74-585b-8a32-5fef5219fe44
DOI: 10.64898/2026.03.27.714785

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